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Article

Prognostic value and immune landscape implications of using a novel homologous recombination repair pathway signature in prostate cancer: A retrospective cohort study.

The Journal of international medical research - 1 Sept 2026

Wang Feng, Tian Y E, Liu Qin, Sha M O, Wang Peng, Huang XueLiang, Tuoheti Kuerban, Chen Jun, Cui Q I

Abstract excerpt

ObjectiveAlthough the homologous recombination repair (HRR) pathway plays a critical role in the treatment of prostate cancer, its prognostic value remains incompletely understood. This study aimed to identify HRR pathway-related biomarkers with clinical utility for prognosis prediction and treatment guidance.MethodsWe analyzed genomic data from The Cancer Genome Atlas and Chinese patients with prostate cancer in...

Read the complete abstract on PubMed

Topics

Humans
Male
Prostatic Neoplasms
Prognosis
Retrospective Studies
Recombinational DNA Repair

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Biomarkers, Tumor

Mutation

Gene Expression Regulation, Neoplastic

Genomic Instability

Source

Identifiers

PMID: 42754412
DOI: 10.1177/03000605261487253

Genes

ARG1
CXCL9
IFNG
KIR2DL3
PDCD1LG2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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