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Article

Genetic evidence for the association between per- and polyfluoroalkyl substances exposure and rheumatoid arthritis risk: A Mendelian randomization study.

Medicine - 21 Aug 2026

Xu Hang, Liu Jiachen, Qiu Xiaorui, He Jiawei, Sun Weichu

Abstract excerpt

Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are persistent environmental pollutants with potential immunotoxic effects. Emerging epidemiological evidence suggests a link between PFAS exposure and autoimmune diseases, including rheumatoid arthritis (RA). However, the causal nature of this relationship remains unclear. Genetic...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42629712
DOI: 10.1097/MD.0000000000050239
PMCID: PMC13502828

Genes

PFAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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