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Article

Donor-recipient HLA molecular mismatch and T follicular helper-related genetic variants are associated with dnDSA development after kidney transplantation.

Frontiers in immunology - 1 Jan 2026

Shidahara Hidetoshi, Ide Kentaro, Yamaoka Aiko, Imaoka Yuki, Shimizu Seiichi, Tahara Hiroyuki, Ohira Masahiro, Tanaka Yuka, Ohdan Hideki

Abstract excerpt

Introduction: De novo donor-specific HLA antibodies (dnDSAs) after kidney transplantation arise through coordinated antigen recognition, T-cell-dependent B-cell activation, and subsequent germinal center reactions. Donor-recipient HLA molecular mismatch reflects donor-derived antigenic disparity and is associated with dnDSA development; however, it does not fully explain interindividual variability in humoral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42519332
DOI: 10.3389/fimmu.2026.1875029
PMCID: PMC13381205

Genes

CTLA4
CXCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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