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Article

Associations between affective distress, alcohol use, and cognitive flexibility: moderating effects of COMT Val158Met genotype.

Frontiers in public health - 1 Jan 2026

Mashburn Cody A, Clarke Emily M, Pearcey Sharon M, Pogue Emily M, Saleem Bilal, Holliday Erica D

Abstract excerpt

Background: Alcohol use is common during emerging adulthood and has been associated with impairments in executive functioning, including cognitive flexibility. Individual differences in affective distress, early life adversity, and genetic variation in dopaminergic signaling pathways may contribute to variability in cognitive flexibility among young adults. The present study examined the relationships among...

Read the complete abstract on PubMed

Topics

Humans
Catechol O-Methyltransferase
Cognitive Flexibility
Genotype
Alcohol Drinking
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Young Adult

Stress, Psychological

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 42745750
DOI: 10.3389/fpubh.2026.1901554
PMCID: PMC13574570

Genes

COMT
CFI

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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Associations between affective distress, alcohol use, and cognitive flexibility: moderating effects of COMT Val158Met genotype.PMID 42745750Read ↗

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