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Article

MIF Promoter Variant rs755622 (-173G/C) in Younger and Older Turkish Adults: An Exploratory Cross-Sectional Genetic and in Silico Analysis.

International journal of molecular sciences - 31 Aug 2026

Ozdilli Kursat, Oztan Gozde, Ogret Yeliz, Oguz Rustu, Ciftci Hayriye Senturk, Aydın Filiz, Oguz Fatma

Abstract excerpt

Age-associated immune-inflammatory remodeling may be influenced by regulatory variation in the macrophage migration inhibitory factor gene (MIF). We conducted an exploratory cross-sectional comparison to assess whether MIF rs755622 (-173G/C) genotype distributions differ between predefined younger and older age groups in a Turkish population and to characterize the observed pattern using genetic-model and in...

Read the complete abstract on PubMed

Topics

Humans
Macrophage Migration-Inhibitory Factors
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

Polymorphism, Single Nucleotide

Cross-Sectional Studies

Female

Middle Aged

Turkey

Intramolecular Oxidoreductases

Aged, 80 and over

Male

Adult

Genotype

Computer Simulation

Alleles

Gene Frequency

Source

Open in PubMed Open full text

Identifiers

PMID: 42737715
DOI: 10.3390/ijms27177818
PMCID: PMC13566417

Genes

MIF
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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