Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study.

doi:10.1016/j.ijid.2024.107232

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Article

Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Nov 2024

Hubacek Jaroslav A, Capkova Nadezda, Bobak Martin, Pikhart Hynek

Abstract excerpt

OBJECTIVES: COVID-19 caused a global pandemic with millions of deaths. Fat mass and obesity-associated gene (FTO) (alias m6A RNA demethylase) and its functional rs17817449 polymorphism are candidates to influence COVID-19-associated mortality since methylation status of viral nucleic acids is an important factor influencing viral viability. METHODS: We tested a population-based cohort of 5233 subjects (aged 63-87...

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PMID: 39244150
DOI: 10.1016/j.ijid.2024.107232
PMCID: PMC11512194

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