Expression of the Human R163C-RYR1 Gain-of-Function Mutation Modified 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Developmental Neurotoxicity in Weanling Mice.

doi:10.3390/ijms27177801

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Article

Expression of the Human R163C-RYR1 Gain-of-Function Mutation Modified 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Developmental Neurotoxicity in Weanling Mice.

International journal of molecular sciences - 31 Aug 2026

Barnhart Christopher D, Wilson Rebecca J, Sethi Sunjay, Chen Hao, Truong Kim M, Kania-Korwel Izabela, Lehmler Hans-Joachim, Pessah Isaac N, Lein Pamela J

Abstract excerpt

Epidemiological studies have identified the developing brain as a target of concern for polychlorinated biphenyls (PCBs). In animal models, behavioral deficits caused by developmental exposure to PCBs have been associated with altered patterns of dendritic arborization in functionally relevant brain regions. In vitro studies revealed that PCB 95 promoted dendritic growth in primary rat hippocampal neuron-glia...

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Topics

Animals
Polychlorinated Biphenyls
Mice
Ryanodine Receptor Calcium Release Channel
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Female

Maze Learning

Mice, Inbred C57BL

Neurotoxicity Syndromes

Mutation

Weaning

Pyramidal Cells

Dendrites

Source

Open in PubMed Open full text

Identifiers

PMID: 42737696
DOI: 10.3390/ijms27177801
PMCID: PMC13565785

Genes

RYR1
TH
CA1

Provenance

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Expression of the Human R163C-RYR1 Gain-of-Function Mutation Modified 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Developmental Neurotoxicity in Weanling Mice.PMID 42737696Read ↗

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