Article
Dual-Hit: Glyphosate exposure at NOAEL level negatively impacts birth and glia-behavioural measures in heterozygous shank3 mutants.
Environment international - 1 Oct 2023
Sakkaki Sophie, Cresto Noemie, Chancel Raphaël, Jaulmes Maé, Zub Emma, Blaquière Marine, Sicard Pierre, Maurice Tangui, Ellero-Simatos Sandrine, Gamet-Payrastre Laurence, Marchi Nicola, Perroy Julie
Abstract excerpt
The omnipresence of environmental contaminants represents a health danger with ramifications for adverse neurological trajectories. Here, we tested the dual-hit hypothesis that continuous exposure to non-observable adverse effect level (NOAEL) glyphosate from pre-natal to adulthood represents a risk factor for neurological-associated adaptations when in the presence of the heterozygote or homozygote mutation of...
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