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Balancing Selection at <i>HLA-G</i> Modulates Fetal Survival, Preeclampsia and Human Birth Sex Ratio

2019-11-22

Abstract excerpt

The population sex ratio is thought to be maintained through balancing selection on rare phenotypes. However, empirical evidence for genetic influence has thus far proven elusive. We combined 1000 Genomes data and large cohorts to study human sex ratios. We found underrepresentation of male offspring in preeclampsia, a serious pregnancy disorder with uncertain pathogenesis. Genetic variation of fetal human leukoc...

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Literature Corpus work
50017a8f-0ad8-526d-956c-56e46b40bbbc
DOI
10.1101/851089
Open publication

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Balancing Selection at <i>HLA-G</i> Modulates Fetal Survival, Preeclampsia and Human Birth Sex RatioDOI 10.1101/851089
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