Article
Distribution of HLA-G extended haplotypes and one HLA-E polymorphism in a large-scale study of mother-child dyads with and without severe preeclampsia and eclampsia.
HLA - 1 Oct 2016
Nilsson L L, Djurisic S, Andersen A-M N, Melbye M, Bjerre D, Ferrero-Miliani L, Hackmon R, Geraghty D E, Hviid T V F
Abstract excerpt
The etiological pathways and pathogenesis of preeclampsia have rendered difficult to disentangle. Accumulating evidence points toward a maladapted maternal immune system, which may involve aberrant placental expression of immunomodulatory human leukocyte antigen (HLA) class Ib molecules during pregnancy. Several studies have shown aberrant or reduced expression of HLA-G in the placenta and in maternal blood in...
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