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Article

Computational analysis of binding between malarial dihydrofolate reductases and anti-folates.

Malaria journal - 2 Mar 2010

Choowongkomon Kiattawee, Theppabutr Sasikrit, Songtawee Napat, Day Nicholas P J, White Nicholas J, Woodrow Charles J, Imwong Mallika

Abstract excerpt

BACKGROUND: Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analogous mutations can be found in the DHFR gene in isolates of Plasmodium vivax (PvDHFR) although anti-folates have not been widely used for the...

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Source

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Identifiers

PMID: 20193090
DOI: 10.1186/1475-2875-9-65
PMCID: PMC2838911

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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