Real-world pharmacogenomics-guided antihypertensive treatment response in clinical practice underrepresented population: implications for precision prescribing and medication safety.

doi:10.1007/s00228-026-04176-7

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Article

Real-world pharmacogenomics-guided antihypertensive treatment response in clinical practice underrepresented population: implications for precision prescribing and medication safety.

European journal of clinical pharmacology - 11 Sept 2026

Alsubaie Nawal, Ilyas Muhammad, Shah Zafar Ali, Binsaleh Ammena Y, Alrossies Amani S, Almazyad Fahad A

Abstract excerpt

BACKGROUND: Pharmacogenomics-guided therapy is a promising approach for optimizing antihypertensive treatment response; however, robust real-world data from South Asian and particularly Pakistani populations remain scarce. Understanding genotype-drug response relationships in this underrepresented population is essential to inform context-specific precision prescribing strategies. OBJECTIVE: To evaluate...

Read the complete abstract on PubMed

Topics

Aged
Female
Humans
Male
Middle Aged
Antihypertensive Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Blood Pressure

Cytochrome P-450 CYP3A

Electronic Health Records

Genotype

Hypertension

Pakistan

Pharmacogenetics

Pharmacogenomic Variants

Precision Medicine

Receptors, Adrenergic, beta-1

Retrospective Studies

South Asian People

Source

Open in PubMed

Identifiers

PMID: 42722881
DOI: 10.1007/s00228-026-04176-7

Genes

ADD1
CYP3A5
ACE
ADRB1
NEDD4L
DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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