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Utilizing Large Electronic Medical Record Data Sets to Identify Novel Drug-Gene Interactions for Commonly Used Drugs.

Clinical pharmacology and therapeutics - 1 Sept 2021

Malki Mustafa Adnan, Dawed Adem Y, Haywood Caroline, Doney Alex, Pearson Ewan R

Abstract excerpt

Real-world prescribing of drugs differs from the experimental systems, physiological-pharmacokinetic models, and clinical trials used in drug development and licensing, with drugs often used in patients with multiple comorbidities with resultant polypharmacy. The increasing availability of large biobanks linked to electronic healthcare records enables the potential to identify novel drug-gene interactions in...

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PMID: 34213766
DOI: 10.1002/cpt.2352

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