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Article

Hypertension pharmacogenetics and limitations in Africa - a focus on the ACE, AGTR1 and CYP2C9 genes.

Journal of human hypertension - 1 Mar 2026

Gomera Rejoice T, van Hougenhouck-Tulleken Wesley, Brand Sarel J, van Niekerk Chantal, Outhoff Kim

Abstract excerpt

Hypertension affects approximately a billion people worldwide and is a major risk for adverse cardiovascular and renal outcomes, particularly in the sub-Saharan African population. Only a small number of treated hypertensive patients achieve blood pressure control. Apart from factors such as poor medication adherence, the limited efficacy of some therapies could be attributed to inter-individual genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

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Share to Peptidyl-Dipeptidase A

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Share to Receptor, Angiotensin, Type 1

Source

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Identifiers

PMID: 41723221
DOI: 10.1038/s41371-026-01121-0
PMCID: PMC13002462

Genes

ACE
AGTR1
CYP2C9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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