Genetic Determinants of Early Heart Failure in Hypoplastic Left Heart Syndrome: A Prospective NC-DEFINE Study.

doi:10.1016/j.jacc.2026.06.031

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Article

Genetic Determinants of Early Heart Failure in Hypoplastic Left Heart Syndrome: A Prospective NC-DEFINE Study.

Journal of the American College of Cardiology - 8 Sept 2026

Balint Brittany N, Sunthankar Sudeep D, Monaco Gabrielle, Bair Courtney A, Wolfe-Miller Rachel, Gonzalez Carla D, Argueta Portillo Cindy S, MacKenzie Duncan, Freedy Katherine, Onorato Angela C, Greskovich Sarah C, Moreland Blythe, Gaither Jeff B, Willoughby Ava, Bigelow Amee M, McBride Kim L, Levin Allison, Kurzlechner Leonie M, Kreinbrook Judah, Ebangawese Santita, Mitchell Saige, Srour Meredith, Macris Sarah, Marusic Sophia, Neuerburg Austin, Farrell Maureen C, Carlson Katherine, Sala Angelina, Girvin Zachary, Lancaster Megan, Gangireddy Srushti, Jaworski James, Wei Wei-Qi, Edwards Todd, Coleman Andersen, Turek Joseph W, Leong Elisabeth, Chiswell Karen, Allen Andrew, Li Jennifer S, White Peter, Kannankeril Prince J, Garg Vidu, Hoffman Timothy M, Landstrom Andrew P

Abstract excerpt

BACKGROUND: Survivors of hypoplastic left heart syndrome (HLHS), the most severe form of congenital heart disease, are at high risk for heart failure (HF). HF in early life is a major contributor to mortality in this vulnerable population. However, reliable approaches to identify infants at highest risk for early HF are currently lacking. OBJECTIVES: The purpose of this study was to evaluate whether ultra-rare...

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Topics

Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hypoplastic Left Heart Syndrome

Heart Failure

Prospective Studies

Male

Female

Infant, Newborn

Genetic Predisposition to Disease

Source

Open in PubMed

Identifiers

PMID: 42714046
DOI: 10.1016/j.jacc.2026.06.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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