Article
Impact of MYH6 variants in hypoplastic left heart syndrome.
Physiological genomics - 1 Dec 2016
Tomita-Mitchell Aoy, Stamm Karl D, Mahnke Donna K, Kim Min-Su, Hidestrand Pip M, Liang Huan Ling, Goetsch Mary A, Hidestrand Mats, Simpson Pippa, Pelech Andrew N, Tweddell James S, Benson D Woodrow, Lough John W, Mitchell Michael E
Abstract excerpt
Hypoplastic left heart syndrome (HLHS) is a clinically and anatomically severe form of congenital heart disease (CHD). Although prior studies suggest that HLHS has a complex genetic inheritance, its etiology remains largely unknown. The goal of this study was to characterize a risk gene in HLHS and its effect on HLHS etiology and outcome. We performed next-generation sequencing on a multigenerational family with...
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