Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recessive MYH6 Mutations in Hypoplastic Left Heart With Reduced Ejection Fraction.

Circulation. Cardiovascular genetics - 1 Aug 2015

Theis Jeanne L, Zimmermann Michael T, Evans Jared M, Eckloff Bruce W, Wieben Eric D, Qureshi Muhammad Y, O'Leary Patrick W, Olson Timothy M

Abstract excerpt

BACKGROUND: The molecular underpinnings of hypoplastic left heart are poorly understood. Staged surgical palliation has dramatically improved survival, yet eventual failure of the systemic right ventricle necessitates cardiac transplantation in a subset of patients. We sought to identify genetic determinants of hypoplastic left heart with latent right ventricular dysfunction in individuals with a Fontan...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Myosins
Share to Echocardiography

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Family Health

Share to Genes, Recessive

Share to Genome, Human

Share to Myosin Heavy Chains

Share to Protein Structure, Tertiary

Share to Stroke Volume

Source

Identifiers

PMID: 26085007
DOI: 10.1161/CIRCGENETICS.115.001070

Genes

MYH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recessive MYH6 Mutations in Hypoplastic Left Heart With Reduced Ejection Fraction.PMID 26085007Read ↗

Impact of MYH6 variants in hypoplastic left heart syndrome.Semantic proximity Read ↗

MYH6 Variants Are Associated with Atrial Dysfunction in Neonates with Hypoplastic Left Heart SyndromeSemantic proximity Read ↗

Genetic Association Between Hypoplastic Left Heart Syndrome and Cardiomyopathies.Semantic proximity Read ↗

MYH6 in Congenital Heart Defects: A Genotype-Phenotype Characterization in a French Cohort.Semantic proximity Read ↗

Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart SyndromeSemantic proximity Read ↗

GATA6 loss-of-function mutations contribute to familial dilated cardiomyopathy.Semantic proximity Read ↗

Compound heterozygous NOTCH1 mutations underlie impaired cardiogenesis in a patient with hypoplastic left heart syndrome.Semantic proximity Read ↗

The Genetic Landscape of Hypoplastic Left Heart Syndrome.Semantic proximity Read ↗

Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart SyndromeSemantic proximity Read ↗

Alpha-cardiac myosin heavy chain (MYH6) mutations affecting myofibril formation are associated with congenital heart defects.Semantic proximity Read ↗

Genome-Wide Association and Inheritance-Based Analyses Implicate Unconventional Myosin Genes in Hypoplastic Left Heart Syndrome.Semantic proximity Read ↗

Human Genetics of Hypoplastic Left Heart Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.