Article
Genome-wide association studies of brain diffusion kurtosis imaging phenotypes.
EBioMedicine - 1 May 2026
Fu Jilian, Wang Jianhua, Xue Hui, Wang Meiyun, Zhang Bing, Zhu Wenzhen, Qiu Shijun, Geng Zuojun, Cui Guangbin, Zhang Quan, Yu Yongqiang, Liao Weihua, Gao Bo, Xu Xiaojun, Han Tong, Yao Zhenwei, Li Mulin Jun, Liu Feng, Liang Meng, Wang Sijia, Xu Qiang, Xu Jiayuan, Zhang Peng, Li Wei, Shi Dapeng, Wang Caihong, Lui Su, Yan Zhihan, Chen Feng, Zhang Jing, Li Jiance, Shen Wen, Miao Yanwei, Wang Dawei, Xian Junfang, Gao Jia-Hong, Zhang Xiaochu, Xu Kai, Zuo Xi-Nian, Zhang Longjiang, Ye Zhaoxiang, Cheng Jingliang, Qin Wen, Zhang Hui, Yu Chunshui
Abstract excerpt
BACKGROUND: As an extension of diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI) quantifies non-Gaussian water diffusion and has been applied to explore brain disorders. However, the genetic architecture of brain DKI phenotypes remains unknown. METHODS: Here, we estimated heritability and conducted genome-wide association studies (GWASs) for 804 DKI phenotypes across 188 brain structures in 4183...
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