HRAS promotes mutant NRAS-driven transformation with codon and allele specificity.

doi:10.1126/scisignal.aej6209

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Article

HRAS promotes mutant NRAS-driven transformation with codon and allele specificity.

Science signaling - 8 Sept 2026

Lee Hyun, Hughes Jacob M, LaMorte Joseph P, Finniff Bridget A, Binette Picabo, Gunasekara Sarasi K, Covas Ariana, Wall Vanessa E, Esposito Dominic, Wilkerson Matthew D, Yohe Marielle E, Kortum Robert L

Abstract excerpt

Wild-type RAS family members determine the signaling and therapeutic response in cancers driven by mutant HRAS and KRAS because they activate alternate RAS effector pathways. Here, we found that the requirement for wild-type RAS to support mutant NRAS-driven transformation correlated with codon-specific differences in GTP hydrolysis. NRAS with mutations at either Gly12 (G12X) or Gly13 (G13X), which retained the...

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Topics

Humans
Cell Transformation, Neoplastic
Animals
Proto-Oncogene Proteins p21(ras)
Membrane Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Alleles

GTP Phosphohydrolases

Mutation

Signal Transduction

Codon

Mice

Guanosine Triphosphate

Phosphatidylinositol 3-Kinases

Source

Open in PubMed

Identifiers

PMID: 42709866
DOI: 10.1126/scisignal.aej6209

Genes

NRAS
HRAS
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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