Article

RAS mutation-specific signaling dynamics in response to paralog- and state- selective RAS inhibitors

2025-02-17

Abstract excerpt

A high therapeutic index (TI), balancing potent oncogenic signaling inhibition in tumor cells with minimal effects on normal cells, is critical for effective cancer therapies. Recent advances have introduced diverse RAS-targeting inhibitors, including mutant-specific inhibitors (e.g., KRAS(G12C) and KRAS(G12D)), as well as paralog- and state-selective inhibitors. Non-mutant-specific RAS inhibition can be accomplis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 48d957e8-4830-53f4-a503-d4b5399108d2
DOI: 10.1101/2025.02.14.638317

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RAS mutation-specific signaling dynamics in response to paralog- and state- selective RAS inhibitorsDOI 10.1101/2025.02.14.638317Read

RAS Mutation-Specific Responses to Paralog- and State-Selective RAS Inhibitors.Semantic proximity Read

The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies.Semantic proximity Read

The evolving landscape of KRAS-targeted therapy: mechanisms of resistance and emerging strategies.Semantic proximity Read

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.Semantic proximity Read

Expanding Addressable KRAS Mutations through the Structure- and Property-Based Design of Dual-State (GDP/GTP), Reversible Pan-KRAS Inhibitors.Semantic proximity Read

RAS, wanted dead or alive: Advances in targeting RAS mutant cancers.Semantic proximity Read

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapySemantic proximity Read

Dual RAF inhibition outperforms RAF-MEK combinations for suppressing ERK signaling in KRAS mutant cells.Semantic proximity Read

Blockade of mutant RAS oncogenic signaling with a special emphasis on KRAS.Semantic proximity Read

Pan-RAS inhibitors: Hitting multiple RAS isozymes with one stone.Semantic proximity Read

RAS-targeted therapies: is the undruggable drugged?Semantic proximity Read

RAS-GTP Inhibition Overcomes Acquired Resistance to KRASG12C Inhibitors Mediated by Oncogenic and Wild-Type RAS Activation in Non-Small Cell Lung Cancer.Semantic proximity Read