Article
Transforming mutations of RAC guanosine triphosphatases in human cancers.
Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2013
Kawazu Masahito, Ueno Toshihide, Kontani Kenji, Ogita Yoshitaka, Ando Mizuo, Fukumura Kazutaka, Yamato Azusa, Soda Manabu, Takeuchi Kengo, Miki Yoshio, Yamaguchi Hiroyuki, Yasuda Takahiko, Naoe Tomoki, Yamashita Yoshihiro, Katada Toshiaki, Choi Young Lim, Mano Hiroyuki
Abstract excerpt
Members of the RAS superfamily of small guanosine triphosphatases (GTPases) transition between GDP-bound, inactive and GTP-bound, active states and thereby function as binary switches in the regulation of various cellular activities. Whereas HRAS, NRAS, and KRAS frequently acquire transforming missense mutations in human cancer, little is known of the oncogenic roles of other small GTPases, including Ras-related...
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