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Article

MiR-326 targets ETS1 to activate PI3K/Akt signaling and promote malignant phenotypes in gastric cancer cells.

Pakistan journal of pharmaceutical sciences - 1 Dec 2026

Liang Kai, Zhang Xiangyu, Yang Yin

Abstract excerpt

BACKGROUND: Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide and effective therapeutic targets remain limited. OBJECTIVES: This study aimed to investigate the expression and functional role of miR-326 in gastric cancer, identify its direct target gene and elucidate the underlying molecular mechanisms involving the PI3K/Akt signaling pathway and the regulation of inflammatory...

Read the complete abstract on PubMed

Topics

Humans
MicroRNAs
Stomach Neoplasms
Proto-Oncogene Proteins c-akt
Proto-Oncogene Protein c-ets-1
Signal Transduction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Line, Tumor

Cell Proliferation

Cell Movement

Phosphatidylinositol 3-Kinases

Apoptosis

Gene Expression Regulation, Neoplastic

Phenotype

Phosphatidylinositol 3-Kinase

Neoplasm Invasiveness

Source

Identifiers

PMID: 42708789
DOI: 10.36721/PJPS.2026.39.12.335.1

Genes

ETS1
GC
CCK
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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