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Article

MicroRNA-128 contributes to the progression of gastric carcinoma through GAREM-mediated MAPK signaling activation.

Biochemical and biophysical research communications - 26 Sept 2018

Han Lu, Xiong Liufang, Wang Cong, Shi Yan, Song Qi, Sun Gang

Abstract excerpt

Gastric carcinoma (GC) represents the most common malignant cancer and the second leading cause of cancer death worldwide. However, the molecular mechanisms and biological progression of GC remain unknown. In this study, we found that miR-128 is a critical tumor suppressor that is downregulated in GC patients and GC cells and that GAREM is a direct downstream target of miR-128. Overexpression of miR-128 in HGC-27...

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PMID: 30177387
DOI: 10.1016/j.bbrc.2018.08.177

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