Rank-guided learning accelerates automated enzyme engineering.

Abstract excerpt

Enzyme catalysis has become a cornerstone of modern synthesis, offering sustainable routes to structurally complex molecules. However, the rugged fitness landscape and limited model capacity to learn from sparse data constrain the development of biocatalysts. Here, we present Rank-guided Exploration for Automated enzyme reProgramming (REAP), a closed-loop platform that combines artificial intelligence with...

Topics

• Protein Engineering
• Bacterial Proteins
• Cytochrome P-450 Enzyme System
• Staphylococcus aureus
• Aminoacyltransferases
• Biocatalysis