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Article

Fasudil regulates T cell responses through polarization of BV-2 cells in mice experimental autoimmune encephalomyelitis.

Acta pharmacologica Sinica - 1 Nov 2014

Chen Chan, Li Yan-hua, Zhang Qiong, Yu Jie-zhong, Zhao Yong-fei, Ma Cun-gen, Xiao Bao-guo

Abstract excerpt

AIM: Fasudil, a selective Rho kinase (ROCK) inhibitor, has been shown to alleviate the severity of experimental autoimmune encephalomyelitis (EAE) via attenuating demyelination and neuroinflammation. The aim of this study was to investigate the effects of fasudil on interactions between macrophages/microglia and T cells in a mice EAE model. METHODS: Mouse BV-2 microglia were treated with IFN-γ and fasudil. Cell...

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Identifiers

PMID: 25263338
DOI: 10.1038/aps.2014.68
PMCID: PMC4220072

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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