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Article

Oncogenic Mutations and Tumor Microenvironment Alterations in Diffuse Large B-Cell Lymphoma With Bulky Disease.

Cancer medicine - 1 Sept 2026

Wang Yu-Qing, Wang Yue, Du Zhi-Shan, Huang Xin-Yun, Dong Yan, Tian Shuang, Fu Di, Cheng Shu, Wang Li, Xu Peng-Peng, Fan Sheng-Jin, Wang Shu-Ye

Abstract excerpt

BACKGROUND: Bulky disease represents a clinically aggressive subset of diffuse large B-cell lymphoma (DLBCL) associated with adverse clinical outcomes. The aim of this study was to investigate the influence of oncogenic mutations and tumor microenvironment alterations on bulky disease in DLBCL. METHODS: We analyzed a cohort of 939 patients with newly diagnosed DLBCL. Using DNA (n = 934) and RNA (n = 524)...

Read the complete abstract on PubMed

Topics

Humans
Lymphoma, Large B-Cell, Diffuse
Tumor Microenvironment
Mutation
Female
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Aged

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 42702822
DOI: 10.1002/cam4.72204
PMCID: PMC13547586

Genes

CD58
EBF1
STAT6
MYC
BCR
CD28
CD4
CD70
ICOS
TIGIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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