The fitness landscape of a form II rubisco in a photosynthetic bacterium guides engineering of oxygen tolerance.

doi:10.1126/sciadv.aee9222

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Article

The fitness landscape of a form II rubisco in a photosynthetic bacterium guides engineering of oxygen tolerance.

Science advances - 4 Sept 2026

Hoffmann Ute A, Knave Axel F, Schuppe Anna Z, Capó-Bauçà Sebastià, Aguiló Nicolau Pere, Schriever Karen, Karlsson Anna, Russo Michele, Sporre Emil, Matsuda Mami, Miao Rui, Hasunuma Tomohisa, Galmés Jeroni, Syrén Per-Olof, Hudson Elton P

Abstract excerpt

Ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco) is an important but challenging protein engineering target. Fast and selective rubiscos could enhance photosynthesis in plants and accelerate biobased production processes. To facilitate engineering of rubisco, we applied an in vivo screen that couples rubisco activity to growth rate of the photoautotrophic cyanobacterium Synechocystis sp. PCC 6803. We...

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Topics

Ribulose-Bisphosphate Carboxylase
Photosynthesis
Oxygen
Synechocystis
Gallionellaceae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phylogeny

High-Throughput Nucleotide Sequencing

Mutagenesis

Epistasis, Genetic

Bioengineering

Genetic Variation

Plants

Source

Open in PubMed Open full text

Identifiers

PMID: 42696565
DOI: 10.1126/sciadv.aee9222
PMCID: PMC13544237

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