Article
A map of the rubisco biochemical landscape.
Nature - 1 Feb 2025
Prywes Noam, Phillips Naiya R, Oltrogge Luke M, Lindner Sebastian, Taylor-Kearney Leah J, Tsai Yi-Chin Candace, de Pins Benoit, Cowan Aidan E, Chang Hana A, Wang Renée Z, Hall Laina N, Bellieny-Rabelo Daniel, Nisonoff Hunter M, Weissman Rachel F, Flamholz Avi I, Ding David, Bhatt Abhishek Y, Mueller-Cajar Oliver, Shih Patrick M, Milo Ron, Savage David F
Abstract excerpt
Rubisco is the primary CO2-fixing enzyme of the biosphere1, yet it has slow kinetics2. The roles of evolution and chemical mechanism in constraining its biochemical function remain debated3,4. Engineering efforts aimed at adjusting the biochemical parameters of rubisco have largely failed5, although recent results indicate that the functional potential of rubisco has a wider scope than previously known6. Here we...
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