Article

Mutant-selective Degradation by BRAF-targeting PROTACs

2020-08-10

Abstract excerpt

Over 300 BRAF missense mutations have been identified in patients, yet currently approved drugs target V600 mutants alone. Moreover, acquired resistance inevitably emerges, primarily due to RAF lesions that prevent inhibition of BRAF V600 with current treatments. Therefore, there is a need for new therapies that target other mechanisms of activated BRAF. In this study, we use the Proteolysis Targeting Chimera (PRO...

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Literature Corpus work: baba67f4-c29a-5808-8ed0-6bfe62e7310e
DOI: 10.1101/2020.08.10.245159

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