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Article

High frequency of LRRK2 p.Gly2019Ser in Moroccan Parkinson's disease: RFLP as a reliable genotyping approach.

Neurogenetics - 2 Sept 2026

El Bardai Sanae, Aboulem Ghita, Ahmadi Youssef, Errazouki Lamyae, Bouhda Najwa, Samri Imane, Abbassi Meriame, Kettani Oussama, El Agy Fatima, Chbani Laila, Messouak Ouafae, Bouguenouch Laila, Belahsen Mohammed Faouzi, Ouldim Karim

Abstract excerpt

The LRRK2 c.6055G>A (p.Gly2019Ser) mutation represents one of the most frequent genetic causes of autosomal dominant Parkinson's disease (PD) worldwide. Morocco exhibits the highest documented global prevalence of this variant, with carrier rates approaching 38.8% among clinically diagnosed patients. This exceptional frequency positions the Moroccan population as a strategic reference point for genotype-driven PD...

Read the complete abstract on PubMed

Topics

Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Morocco
Parkinson Disease
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Genotype

Genotyping Techniques

Gene Frequency

Mutation

Source

Identifiers

PMID: 42684504
DOI: 10.1007/s10048-026-00936-w

Variants

Provenance

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