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Article

Integrative Multi-Omics Mendelian Randomization Analysis Identifies NIT2 as a Potential Metabolic Risk Gene in Hepatocellular Carcinoma.

The journal of gene medicine - 1 Sept 2026

Liao Ziyue, Fang Qinghua, Chen Yue, Yang Xiangyu, Wu Haijuan, Wang Hongyang, Gao Jian

Abstract excerpt

BACKGROUND: Metabolic pathways are crucial in hepatocellular carcinoma (HCC) pathogenesis, but causal metabolic genes remain unclear. This study used Summary data-based Mendelian Randomization (SMR) and colocalization to identify metabolism-related genetic loci influencing HCC risk. METHODS: Differentially expressed genes in hepatic malignancy phenotype versus normal tissues from TCGA and GTEx were analyzed....

Read the complete abstract on PubMed

Topics

Carcinoma, Hepatocellular
Liver Neoplasms
Humans
Mendelian Randomization Analysis
Multiomics
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Gene Expression Regulation, Neoplastic

Aminohydrolases

Polymorphism, Single Nucleotide

DNA Methylation

Source

Open in PubMed Open full text

Identifiers

PMID: 42681890
DOI: 10.1002/jgm.70111
PMCID: PMC13534973

Genes

NIT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 27 Oct 2026.

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