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Article

HLA-A ∗01:01 Allele Is Associated With Increased Risk of Transplant-Related Mortality After MHC Matched Unmodified Allogeneic Hematopoietic Stem Cell Transplantation.

Journal of immunology research - 1 Jan 2026

Cowen Emily A, Brown Samantha, Reingold Rachel E, Samorodnitsky Sarah, Fonseca Maira, Stoll Joseph R, Devlin Sean M, Young James W, Fatmi Samira A, Maloy Molly, Giralt Sergio, Ponce Doris M, Jakubowski Ann A, Markova Alina

Abstract excerpt

Acute graft-versus-host disease (aGvHD) remains a substantial cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HCT). Limited studies explore the association between specific major histocompatibility complex (MHC) alleles and aGvHD or transplant-related mortality (TRM). After a noted clinical trend of higher TRM among a series of patients with aGvHD and MHC class I HLA- A...

Read the complete abstract on PubMed

Topics

Humans
Hematopoietic Stem Cell Transplantation
Female
Graft vs Host Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Male

Alleles

Transplantation, Homologous

Middle Aged

HLA-A Antigens

Retrospective Studies

Histocompatibility

Risk Factors

Histocompatibility Testing

Young Adult

Aged

Adolescent

Source

Open in PubMed Open full text

Identifiers

PMID: 42671266
DOI: 10.1155/jimr/7237488
PMCID: PMC13528444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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