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Article

HLA-B Leader and Survivorship after HLA-Mismatched Unrelated Donor Transplantation

1 Jun 2020

Abstract excerpt

Hematopoietic cell transplantation (HCT) from HLA-mismatched unrelated donors can cure life-threatening blood disorders, but its success is limited by graft-versus-host disease (GVHD). HLA-B leaders encode methionine (M) or threonine (T) at position 2 and give rise to TT, MT, or MM genotypes. The dimorphic HLA-B leader informs GVHD risk in HLA-B-mismatched HCT. If the leader influences outcome in other...

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PMID: 32483623
DOI: 10.1182/blood.2020005743

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