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Article

ADHD-anchored partitioning of non-small cell lung cancer genetic covariance identifies CLPTM1L and suggestive innate-immune signals.

Frontiers in immunology - 1 Jan 2026

Yu Ting, Wang Peng, Zheng Ziwei, Zhao Kun, Yan Gang, Song Jiawen, Yi Xinglin, Yang Shaoling, Jiang Zhibiao

Abstract excerpt

Background: Individuals with attention-deficit/hyperactivity disorder (ADHD) show an elevated incidence of non-small cell lung cancer (NSCLC), usually attributed to smoking. Innate immune activation and chronic inflammation are implicated in both, yet whether shared germline genetics include a component statistically independent of the measured current-smoking phenotype, and whether that liability has an innate...

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Identifiers

PMID: 42661613
DOI: 10.3389/fimmu.2026.1913958
PMCID: PMC13518126

Genes

CLPTM1L

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