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Article

Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis.

BMC medicine - 5 Feb 2026

Song Jiahang, Li Pengzhu, Canis Martin, Unger Kristian, Haas Nikolaus Alexander, Gires Olivier

Abstract excerpt

BACKGROUND: Psychoactive substance use (PSU) and cancer are frequently observed comorbidities that have reciprocal influences and shared behavioral traits of the affected patients. While, e.g., nicotine and alcohol are major carcinogens in the etiology of lung and head and neck cancers, little is known about a shared overarching genetic architecture of PSU and cancer that may predispose individuals to both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41645249
DOI: 10.1186/s12916-026-04677-3
PMCID: PMC12930682

Genes

CHRNA2
HRH3
PTK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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