Article
Insights into the Identification of iPSC- and Monocyte-Derived Macrophage-Polarizing Compounds by AI-Fueled Cell Painting Analysis Tools.
International journal of molecular sciences - 17 Nov 2024
Brüggenthies Johanna B, Dittmer Jakob, Martin Eva, Zingman Igor, Tabet Ibrahim, Bronner Helga, Groetzner Sarah, Sauer Julia, Dehghan Harati Mozhgan, Scharnowski Rebekka, Bakker Julia, Riegger Katharina, Heinzelmann Caroline, Ast Birgit, Ries Robert, Fillon Sophie A, Bachmayr-Heyda Anna, Kitt Kerstin, Grundl Marc A, Heilker Ralf, Humbeck Lina, Schuler Michael, Weigle Bernd
Abstract excerpt
Macrophage polarization critically contributes to a multitude of human pathologies. Hence, modulating macrophage polarization is a promising approach with enormous therapeutic potential. Macrophages are characterized by a remarkable functional and phenotypic plasticity, with pro-inflammatory (M1) and anti-inflammatory (M2) states at the extremes of a multidimensional polarization spectrum. Cell morphology is a...
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