Analysis of Allele-Specific Expression Highlights Novel Participants of Empagliflozin-Driven Effects on T2DM-Associated Regulatory Pathways.

doi:10.3390/ijms27167202

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Article

Analysis of Allele-Specific Expression Highlights Novel Participants of Empagliflozin-Driven Effects on T2DM-Associated Regulatory Pathways.

International journal of molecular sciences - 12 Aug 2026

Korbolina Elena E, Gubina Maria, Bryzgalov Leonid O, Degtyareva Arina O, Evseenko Anastasia A, Antonseva Elena V, Korbut Anton I, Rykova Elena Y, Klimontov Vadim V, Kzhyshkowska Julia G, Merkulova Tatiana I

Abstract excerpt

It is well-known that the morbidity and clinical burden of type 2 diabetes mellitus (T2DM) are predominantly associated with its chronic complications, in which fibrosis is a significant contributor. Recently, sodium-glucose cotransporter 2 (SGLT2) inhibitors have made a pivotal advancement in the therapeutic landscape not only improving glycemic control, but also demonstrating high effectiveness in the...

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