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Article

Driver mutation impact in Chinese hepatocellular carcinoma.

PloS one - 1 Jan 2026

Wu Ruiheng, Xing Houmin, Townsend Jeffrey P

Abstract excerpt

Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality in China. The Chinese Liver Cancer Atlas (CLCA) recently reported whole-genome sequencing of 494 HCC tumors, nominating 23 coding and 31 non-coding driver candidates based on combined P values across multiple algorithms. However, the statistical significance of recurrence alone does not distinguish functionally impactful drivers from...

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Source

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Identifiers

PMID: 42636226
DOI: 10.1371/journal.pone.0355717
PMCID: PMC13502700

Genes

CTNNB1
IL6ST
P4HA1
STAT3
TERT
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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