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Article

Functional Interpretation of Recurrent Genetic Variants in Hepatocellular Carcinoma: Molecular Consequences and Clinical Relevance.

Human mutation - 1 Jan 2026

Ye Yuntao, Xu Zhulin, Wang Jiang, Chen Chunyu, Peng Yuan, Li Bo

Abstract excerpt

Hepatocellular carcinoma (HCC) is characterized by substantial molecular heterogeneity shaped by recurrent genetic alterations. Large-scale genomic studies have defined the mutational landscape of HCC, but the biological interpretation and clinical utility of these variants remain incompletely established. Increasing evidence suggests that key driver alterations influence tumor behavior not only through direct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42253501
DOI: 10.1155/humu/6223429
PMCID: PMC13240498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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