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Article

Multimodal Meta-Analysis of 1,494 Hepatocellular Carcinoma Samples Reveals Significant Impact of Consensus Driver Genes on Phenotypes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2019

Chaudhary Kumardeep, Poirion Olivier B, Lu Liangqun, Huang Sijia, Ching Travers, Garmire Lana X

Abstract excerpt

Although driver genes in hepatocellular carcinoma (HCC) have been investigated in various previous genetic studies, prevalence of key driver genes among heterogeneous populations is unknown. Moreover, the phenotypic associations of these driver genes are poorly understood. This report aims to reveal the phenotypic impacts of a group of consensus driver genes in HCC. We used MutSigCV and OncodriveFM modules...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30242023
DOI: 10.1158/1078-0432.CCR-18-0088
PMCID: PMC6542354

Genes

TP53
CTNNB1
ALB
ARID1A
AXIN1
CDKN2A
RB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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