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Article

Analysis of genetic mutation characteristics in 40 Chinese patients with hepatocellular carcinoma.

Genes & genomics - 1 Apr 2026

Xu Shaoshao, Li Lei, Yang Dongchang, Liu Tao, Liu Binyu, Xun Qingqing, Liu Yanrong

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is notable for its marked molecular heterogeneity and poor response to systemic therapy. Targeted next-generation sequencing (NGS) has facilitated the profiling of somatic alterations in HCC. However, the interpretation of panel-based genomic features such as tumor mutational burden (TMB), copy number alterations, and candidate gene fusions remains challenging,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41661474
DOI: 10.1007/s13258-026-01743-1

Genes

KIT
PDGFRA
ROS1
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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