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A single-cell transcriptome atlas reveals paradoxical monoallelic expression of RNA editing and heterozygous SNPs.

Nucleic acids research - 24 Aug 2026

Duan Yuange, Liu Jiyao, Xu Shiwen, Xie Qiuhua, Ma Ling, Song Fan, Tian Li, Cai Wanzhi, Cao Qi, Li Hu

Abstract excerpt

Both genomic mutations and RNA editing contribute to functional complexity and drive adaptive evolution. Single-cell profiling offers deep insight into the cis-regulatory mechanisms underlying these variations. Using 13 025 single-cell Smart-Seq libraries from whole-body Drosophila melanogaster, we unexpectedly found that 94.0% of adenosine-to-inosine RNA editing sites and 92.8% of heterozygous single nucleotide...

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Identifiers

PMID: 42635128
DOI: 10.1093/nar/gkag846
PMCID: PMC13501139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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