Article
EZH2 mutations in follicular lymphoma from different ethnic groups and associated gene expression alterations.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2014
Guo Shuangping, Chan John K C, Iqbal Javeed, McKeithan Timothy, Fu Kai, Meng Bin, Pan Yi, Cheuk Wah, Luo Donglan, Wang Ruian, Zhang Weiwei, Greiner Timothy C, Chan Wing C
Abstract excerpt
PURPOSE: Gain-of-function mutations of enhancer of Zeste homolog 2 (EZH2) occur frequently in diffuse large B-cell lymphomas and in follicular lymphomas. However, the frequency of EZH2 mutation in Chinese follicular lymphomas and the potential targets affected by this mutation are unknown. EXPERIMENTAL DESIGN: We determined EZH2 codon 641 mutations in Chinese follicular lymphomas (n = 124) and compared them with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.