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Potential causal associations between perfluoroalkyl substances exposure and adverse pregnancy outcomes: A bidirectional two-sample mendelian randomization study

29 Nov 2024

Abstract excerpt

Maternal exposure to per- and polyfluoroalkyl substances (PFASs) has been linked to adverse pregnancy outcomes (APOs). Nonetheless, the genetic causality underlying this association remains unknown. This research employed a bidirectional two-sample Mendelian randomization (MR) to investigate the potential causal associations between PFASs exposure and APOs risk. PFASs data were sourced from the GWAS Catalog, and...

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PMID: 39615299
DOI: 10.1016/j.ecoenv.2024.117374

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