Article
Genomic alterations and clinical outcomes in patients with lung adenocarcinoma with transformation to small cell lung cancer after treatment with EGFR tyrosine kinase inhibitors: A multicenter retrospective study.
Lung cancer (Amsterdam, Netherlands) - 1 May 2021
Wang Wenxian, Xu Chunwei, Chen Huafei, Jia Jinhao, Wang Liping, Feng Huijing, Wang Hong, Song Zhengbo, Yang Nong, Zhang Yongchang
Abstract excerpt
BACKGROUND: Transformation to small cell lung cancer (SCLC) is a resistance mechanism to tyrosine kinase inhibitor (TKI) treatment that develops in lung adenocarcinoma. The genomic and treatment outcomes in these populations have not been comprehensively reported in China. METHODS: We performed a retrospective study analyzing patients with advanced non-SCLC (NSCLC) from eight sites who were diagnosed with SCLC...
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