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Article

A TBK1 mutation disrupting IRF3 activation is associated with familial recurrent myopericarditis.

Frontiers in immunology - 1 Jan 2026

Peet Claire J, Orchard Thomas, Cruz Carlos H B, Hernandez-Cordero Ariana, Omoyinmi Ebun, Mahil Satveer K, Lachmann Helen J, Fraternali Franca, Capon Francesca

Abstract excerpt

Introduction: Idiopathic recurrent pericarditis (IRP) is an immune-mediated disease characterized by episodes of pericardial inflammation. While IRP is increasingly considered an autoinflammatory condition, pathogenic pathways remain poorly understood. In this context, gene discovery can reveal new disease mechanisms. Methods: We carried out whole-exome sequencing in a pedigree where three individuals suffered...

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Identifiers

PMID: 42620317
DOI: 10.3389/fimmu.2026.1906965
PMCID: PMC13485522

Genes

TBK1
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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