Article
Beyond differential expression: Differential variability as an underappreciated axis in transcriptomics.
Cell systems - 19 Aug 2026
Jiang Chenxin Flora, Wang Changhu, Li Jingyi Jessica
Abstract excerpt
Differential expression has long been the default lens for comparing transcriptomes between conditions, but mean shifts alone can miss important biological signals. Using a recent debate on memory-associated transcriptome changes, this commentary highlights differential variability as an underappreciated axis for interpreting transcriptome variation.
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