Article
RNA: state memory and mediator of cellular phenotype.
Trends in cell biology - 1 Jun 2010
Kim Junhyong, Eberwine James
Abstract excerpt
It has become increasingly clear that the genome is dynamic and exquisitely sensitive, changing expression patterns in response to age, environmental stimuli and pharmacological and physiological manipulations. Similarly, cellular phenotype, traditionally viewed as a stable end-state, should be viewed as versatile and changeable. The phenotype of a cell is better defined as a 'homeostatic phenotype' implying...
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