Article
Progress and new challenges in image-based profiling.
Molecular systems biology - 1 May 2026
Serrano Erik, Peters John, Wagner Jesko, Graham Rebecca E, Chen Zhenghao, Feng Brian Y, Miranda Gisele, Kalinin Alexandr A, Vulliard Loan, Tomkinson Jenna, Mattson Cameron, Lippincott Michael J, Kang Ziqi, Sitani Divya, Bunten Dave, Seal Srijit, Carragher Neil O, Carpenter Anne E, Singh Shantanu, Marin Zapata Paula A, Caicedo Juan C, Way Gregory P
Abstract excerpt
For over two decades, image-based profiling has revolutionized cell phenotype analysis. Image-based profiling processes rich, high-throughput, microscopy data into thousands of unbiased measurements that reveal phenotypic patterns powerful for drug discovery, functional genomics, and cell state classification. Here, we review the evolving computational landscape of image-based profiling, detailing the...
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