Article
Selective Cell Death of Adrenocortical Cells by Pharmacological Activation of Mutant KCNJ5.
Hypertension (Dallas, Tex. : 1979) - 1 Oct 2026
Mir-Bashiri Sanas, Rakete Stefan, Wei Jia, Peitzsch Mirko, Hahner Stefanie, Reincke Martin, Williams Tracy Ann
Abstract excerpt
BACKGROUND: Primary aldosteronism is frequently caused by mutations in the KCNJ5 (potassium inwardly rectifying channel subfamily J member 5) gene, encoding a G-protein inwardly rectifying potassium channel. These mutations disrupt the channel's selectivity filter, permitting abnormal sodium influx. We aimed to identify compounds that selectively activate mutant KCNJ5 channels. By further increasing sodium...
Read the complete abstract on PubMedTopics
- Humans
- G Protein-Coupled Inwardly-Rectifying Potassium Channels
- Adrenal Cortex
- Mutation
- Cell Death
- Hyperaldosteronism